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随着非类固醇抗炎药(NSAIDS)目用或处方的逐渐增多,医生和服用者都有必要熟悉这类药物的副作用。非类固醇抗炎药物至少有一种共同的副作用,即抑制前列腺素(PGs)的合成。这些药物的许多治疗作用以及可能的副作用都和这一作用有关。“前列腺素样物”(Prostanoids)是含有前列腺素(PGs)与血栓素(thromboxane)的一种化合物,它们存在许多器官和组织中,包括肾脏在内。由20个碳必需脂肪酸(20-Carbon essential fatty acid)、花生四烯酸(arachidonic acid)所形成。前列腺素是经过一系列酶的反应所形成
As non-steroidal anti-inflammatory drugs (NSAIDS) increase their use or prescription, it is necessary for both physicians and users to become familiar with the side effects of such drugs. Non-steroidal anti-inflammatory drugs have at least one common side effect of inhibiting the synthesis of prostaglandins (PGs). Many of the therapeutic effects of these drugs and possible side effects are related to this effect. Prostanoids are a class of compounds that contain prostaglandins (PGs) and thromboxanes and are found in many organs and tissues, including the kidneys. It consists of 20-carbon essential fatty acids and arachidonic acid. Prostaglandins are formed by a series of enzymatic reactions