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目的比较以埃索美拉唑(EMZ)为基础的高剂量和标准剂量三联疗法治疗幽门螺杆菌(HP)感染者的临床疗效。方法选取2015年6月~2016年6月接受医治的80例幽门螺杆菌感染患者临床资料,依据给药方式的不同,分设为治疗组(40例)及对照组(40例),对照组行标准剂量克拉霉素(CLT)+阿莫西林(AMX)+埃索美拉唑(EMZ)医治,对照组每次服用20 mg EMZ,每日2次;每次服用1 000 mg AMX,每日2次;每次服用500 mg CLT,每日2次,疗程10 d。治疗组行高剂量CLT+AMX+EMZ医治,每次服用400 mg EMZ,每日2次,其他药物服用量同对照组,疗程10 d。比较两组治疗前后各项症状积分、症状改善、幽门螺杆菌根除情况以及不良反应情况。结果治疗前两组各项症状积分比较,差异无统计学意义(P>0.05),治疗后治疗组各项症状积分、症状改善及HP根除情况优于对照组,差异有统计学意义(P<0.05);两组不良反应情况比较,差异无统计学意义(P>0.05)。结论 HP感染者行高剂量克拉霉素联合阿莫西林与埃索美拉唑医治,可改善临床症状,并提高HP的根除率,而且不良反应轻微。
Objective To compare the clinical efficacy of esomeprazole (EMZ) -based high-dose and standard-dose triple therapy in the treatment of Helicobacter pylori (HP) infection. Methods The clinical data of 80 patients with Helicobacter pylori infection who were treated from June 2015 to June 2016 were selected and divided into treatment group (40 cases) and control group (40 cases) according to different administration modes. The control group The standard dose of clarithromycin (CLT) + amoxicillin (AMX) + esomeprazole (EMZ) treatment, the control group taking 20 mg EMZ twice daily, taking 1000 mg AMX, daily 2 times; taking 500 mg CLT twice daily for 10 days. Treatment group high dose CLT + AMX + EMZ treatment, taking 400 mg EMZ twice a day, taking the other drugs with the control group, treatment of 10 d. The symptom score, symptom improvement, Helicobacter pylori eradication and adverse reactions were compared between the two groups before and after treatment. Results There was no significant difference in symptom scores between the two groups before treatment (P> 0.05). After treatment, all symptom scores, symptom improvement and HP eradication were better in the treatment group than in the control group (P < 0.05). There was no significant difference in adverse reactions between the two groups (P> 0.05). Conclusion HP infection with high-dose clarithromycin combined with amoxicillin and esomeprazole treatment can improve clinical symptoms, and improve the eradication rate of HP, and mild adverse reactions.