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利用免疫组织化学LSAB法,观察了51例子宫颈鳞状细胞癌中bcl2和bax基因产物的表达,以探讨bcl2和bax与该肿瘤临床病理特征及患者预后的关系。结果表明,51例子宫颈鳞癌中,4313%(22/51)bcl2产物阳性,5294%(27/51)bax产物阳性。在分化程度高、无淋巴结转移患者中,bcl2高表达。在临床分期晚、分化程度低、有淋巴结转移患者中,bax高表达。bcl2和bax表达间呈负相关。提示bcl2和bax基因蛋白均参与了子宫颈鳞癌的发生发展过程,有着不同的生物学作用
The expression of bcl2 and bax gene in 51 cases of cervical squamous cell carcinoma was observed by immunohistochemistry LSAB method to explore the relationship between bcl2 and bax and the clinicopathological features and prognosis of the patients. The results showed that in 51 cases of cervical squamous cell carcinoma, 43.13% (22/51) were positive for bcl-2 and 52.94% (27/51) for bax. In a high degree of differentiation, no lymph node metastasis, bcl 2 expression. Late in the clinical stage, low differentiation, patients with lymph node metastasis, bax high expression. bcl 2 and bax expression was negatively correlated. Tip bcl 2 and bax gene proteins are involved in the development of cervical squamous cell carcinoma has a different biological role