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实验在雄性成年SD大鼠上进行,麻醉后气管插管,用人工呼吸机经气袋自发吸入9%低氧气体,并记录左心室内压。结果:(1)急性低氧时左心室内压显著降低,而低氧后静脉注射不同剂量的纳洛酮(1mg/kg/mL、5mg/kg/mL)则可以部分逆转急性低氧时左心室内压的下降。(2)第四脑室注射2μL纳洛酮(1μg/μL)也可以部分逆转急性低氧时体内内啡肽系统可能参与急性低氧时的左心室内压的下降,而内啡肽拮抗剂纳洛酮则部分对抗急性低氧时左心室内压的下降。
The experiment was carried out in male adult SD rats. After anesthesia, the tracheal intubation was carried out. The spontaneous inhalation of 9% hypoxia gas through the air bag with a respirator was performed and the left ventricular pressure was recorded. Results: (1) Left ventricular pressure was significantly decreased in acute hypoxia, while intravenous injection of naloxone (1mg / kg / mL, 5mg / kg / mL) after hypoxia partially reversed the left ventricular pressure Declination of ventricular pressure. (2) Injection of 2 μL naloxone (1 μg / μL) into the fourth ventricle also partially reversed the decrease of left ventricular pressure when the endorphin system in acute hypoxia was involved in acute hypoxia, whereas endorphin antagonist Na Losone partially antagonizes the decline in left ventricular pressure during acute hypoxia.