蛋白质表面上亲水性基团的溶剂化以及它们之间的相互作用在蛋白质的许多生化过程中起到重要的作用 [1 ] .文献曾报道过许多具有双亲水性基团的化合物在水溶液中的体积性质 ,如 α,ω-二醇 ,α,ω-氨基酸 ,α,ω-二酸 ,得出的结论是 :分子中双亲水性基团在一定的距离内会互相干 Solvation of hydrophilic groups on the surface of proteins and the interactions between them play an important role in many biochemical processes of proteins.1 Many compounds with amphipathic groups in aqueous solution have been reported Volumetric properties such as alpha, omega-diols, alpha, omega-amino acids, alpha, omega-diacids conclude that amphipathic hydrophilic groups will co-dry to one another within a certain distance