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目的:比较改良法白细胞去除术与传统白细胞去除术在高白细胞白血病治疗中的疗效及不良反应。方法:以84例高白细胞白血病患者为研究对象,其中43例采用改良法白细胞去除术联合化疗(改良组),41例采用传统白细胞去除术联合化疗(传统组)。观察2组白细胞去除前后血细胞的变化、去除术中的不良反应发生率及临床疗效。结果:2种方法都能起到有效清除白血病细胞的作用。改良组去除时间较传统组明显缩短[(127±11)min∶(220±8)min,P<0.05],低血钙和低血容量症状发生率亦明显低于传统组(14.0%∶31.7%,14.0%∶31.7%,均P<0.05)。结论:改良法白细胞去除术清除白血病细胞的效果与传统方法相当,且去除时间缩短,低血钙、低血容量症状等不良反应发生率降低,值得临床推广应用。
Objective: To compare the efficacy and adverse reactions of modified leukopenia and traditional leucopenia in the treatment of leukemia. Methods: Eighty - four patients with leukemia were enrolled in this study. Forty - three patients were treated with modified leucopenia combined with chemotherapy (modified group) and 41 with conventional leukapheresis combined with chemotherapy (traditional group). The changes of blood cells in two groups before and after leukocyte removal were observed, and the incidence of adverse reactions and the clinical efficacy were removed. Results: Both methods can effectively remove the leukemic cells. The time of removal of hypocalcemia and hypovolemia in the modified group was significantly shorter than that in the traditional group [(127 ± 11) min: (220 ± 8) min, P <0.05] %, 14.0%: 31.7%, all P <0.05). CONCLUSION: The modified leucocyte removal method is effective in removing leukemic cells. Compared with the traditional methods, the removal efficiency of leukemic cells is shortened, and the incidence of adverse reactions such as hypocalcemia and hypovolemia symptoms is reduced. It is worthy of clinical application.