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对96例新鲜大肠腺癌组织17p等位基因丢失分析显示，17p等位基因丢失频率与大肠腺癌的部位、Dukes＇分期和大肠癌转移相关。Dukes＇D期17p等位基因丢失频率（94％）高于Dukes＇A、B、C期（58～68％），P＜0．01。大肠腺癌伴远处器官转移组17p等位基因丢失（93％）高于非远处器官转移组（65％），P＜0.05。左半结肠17p等位基因丢失频率（75％），高于右半结肠（50％），P＜0.05。上述结果表明，17p等位基因丢失可能是晚期大肠腺癌的生物学标记，显示大肠腺癌预后不佳。
Analysis of the 17p allele loss in 96 fresh colorectal adenocarcinoma tissues revealed that the 17p allele loss frequency is associated with the location of colorectal adenocarcinoma, Dukes’ stage, and metastasis of colorectal cancer. The frequency of 17p allele deletion in Dukes’D stage (94%) was higher than Dukes’A, B, and C stage (58 to 68%), P<0.01. The 17p allele loss (93%) was greater in the colorectal adenocarcinoma with distant organ metastasis group than in the non-distant organ metastasis group (65%), P<0.05. The frequency of 17p allele loss in the left colon was higher (75%) than in the right colon (50%), P<0.05. The above results indicate that the 17p allele loss may be a biological marker of advanced colorectal adenocarcinoma, indicating poor prognosis of colorectal adenocarcinoma.