应用自拟固本行水汤配合强的松治疗难治性肾病综合征３２例。结果：基本痊愈２７例，完全缓解２例，部分缓解１例，无效２例。完全缓解率９０．６％，总有效率为９３．７％。本方采用从缓补脾肾着手，兼以活血利湿的方法，可以有效地疏导三焦壅滞，有利水湿在体内运化、输布及排泄，从而达到改着肾功能，消除水肿的目的。 Thirty - two cases of refractory nephrotic syndrome were treated with self - made Guben Decoction and prednisone. Results: The basic recovery in 27 cases, complete remission in 2 cases, partial remission in 1 case, 2 cases. The complete remission rate was 90.6%, the total effective rate was 93.7%. The side of the start from the buffer of spleen and kidney, and to promote blood circulation method, can effectively divert the triple burner stagnation, beneficial water wet in the body transport, delivery and excretion, so as to achieve the purpose of changing kidney function, eliminate edema .