20 0 0年以来 ,我们采用二甲双胍治疗葡萄糖耐量减低 40例 ,经过两年的随访观察 ,表明二甲双胍可明显降低糖耐量减低发展成糖尿病的机率。1　对象门诊葡萄糖耐量减低患者 80例 ,男 43例 ,女 3 7例 ;年龄3 5～ 65岁 ,平均 5 0± 8岁 ,所有病例符合国际糖尿病联盟(ＩＤＦ) 1997年 Metformin was used to treat 40 patients with impaired glucose tolerance after 20 years of treatment. After two years of follow-up, metformin significantly reduced the incidence of impaired glucose tolerance and reduced development of diabetes mellitus. One outpatient 80 patients with impaired glucose tolerance, 43 males and 37 females; aged 35 to 65 years (mean, 50 ± 8 years). All cases were in accordance with the International Diabetes Federation (IDF) in 1997