VEGFR相关论文
子宫内膜癌(endometrial cancer,EC)是最常见的妇科恶性肿瘤之一,近年来EC的发病率和死亡率都有上升的趋势,晚期、转移和复发患者......
血管内皮生长因子VEGF及其受体VEGFR是脊椎动物血管生成的重要促进因子，而在文昌鱼中尚无相关研究。通过基因组数据库搜索，可以在佛......
目的:我们的目的旨在研究阿帕替尼在转移或局部复发鼻咽癌（NPC）患者中的疗效和安全性。方法:一项多中心、单臂、前瞻性II期临床研究......
目的:分析阿帕替尼(apatinib,YN968D1)单药治疗晚期恶性肿瘤的疗效及不良反应。方法:检索Embase、PubMed、中国知网数据库,使用RSt......
目的探讨神经细胞中的胱硫醚β合成酶(CBS)催化生成的H2S对小鼠脑血管内皮细胞增殖、迁移的影响及其与VEGFR 2的关系。方法用CCK-8......
Angiogenesis plays a pivotal role in the formation and homeostasis of blood vessels during embryonic and postnatal d......
Vorolanib,an oral VEGFR/PDGFR dual tyrosine kinase inhibitor for treatment of patients with advanced
Objective:This study evaluated the safety and preliminary efficacy of vorolanib,a novel tyrosine kinase inhibitor,for tr......
Expression of vascular endothelial growth factor and its receptors VEGFR-1 and 2 in gastrointestinal
AIM: To investigate the role of vascular endothelial growth factor (VEGF) and its receptors VEGFR-1 and 2 in the growth ......
血管内皮细胞生长因子(VEGF)在维持肿瘤微脉管系统中发挥了重要作用,针对其进行抗新生血管的治疗已成为肿瘤治疗的新靶点。VEGF受......
弥漫浸润型星形细胞瘤占成人恶性脑肿瘤的大多数,临床上最大的问题是因其广泛浸润的特性而无法完全切除。多形性胶质母细胞瘤(glio......
淋巴管转移是胃肠道肿瘤最基本的转移途径,也是患者死亡的主要原因。近年来随着淋巴内皮细胞特异性标记物的发现和对淋巴管生成的......
目的探讨血管内皮生长因子C(vascular endothelial growth factor C,VEGF-C)在胰腺癌淋巴管生成及其与淋巴结转移中的作用。方法采......
Malignant melanoma of the skin preferentially metastasises viathe lymphatic system. Novel molecular biomarkers, which ar......
Carvedilol may attenuate liver cirrhosis by inhibiting angiogenesis through the VEGF-Src-ERK signali
AIM: To investigate the effect of carvedilol on angiogenesis and the underlying signaling pathways.METHODS: The effect o......
目的 研制能封闭血管内皮生长因子（ＶＥＧＦ）受体ＫＤＲ的单克隆抗体（ＭｃＡｂ）?探讨其抑制ＶＥＧＦ诱导的体内外活性。方法 以原核表达的ＫＤＲⅠ￣Ⅳ区融合蛋白免疫ＢＡＬＢ／ｃ小鼠，用......
甲状腺癌是内分泌最常见的恶性肿瘤,近年许多资料显示甲状腺癌在全球发病率有逐年上升趋势,每年增长约4%[1],甲状腺乳头状癌(papil......
自２０世纪７０年代Folkman首先提出肿瘤的生长和转移依赖于肿瘤组织内新生的血管以来，研究者对于血管形成与肿瘤的增殖、转移的关系极为重......
目的 研究转移相关基因VEGF-C在甲状腺癌中的表达及其临床意义。方法 应用免疫组化方法检测45例甲状腺癌组织中的VEGF-C的表达情况......
血管内皮生长因子,又称血管通透因子是一种多功能的细胞因子。它具有促进血管内皮细胞的增殖,迁移,诱导血管生成减少凋亡,神经保护......
肿瘤血管生成或肿瘤内血管形成对癌细胞的存活、局部肿瘤的生长和远处转移起重要作用,新生血管可向生长肿瘤提供充足的氧气和营养,......
目的研究白藜芦醇促进斑马鱼尾鳍再生的活性及作用机制,并研究其对斑马鱼胚胎发育的影响,为白藜芦醇药效的进一步开发和安全用药提......
Multi-target agents against tyrosine kinases and topoisomerases are potentially useful for the effective treatment of ca......
2月份的类风湿学杂志报道:日本研究者发现一种可溶性血管上皮生长因子受体1(VEGFR1),即嵌合蛋白,可以通过直接抑制血管增生来治疗......
To analyze the expression of vascular endothelial growth factor A (VEGF- A) and receptors (VEGFR- 1 and VEGFR- 2) in end......
Discovery and synthesis of N~2,N~4-substitued-cycloalkyl[d]pyrimidine-2,4-diamine analogs: The first
A series of novel, cycloalkyl-modified pazopanib analogs 2 and 3 were designed and synthesized. Their kinase modulatory ......
急性肺损伤(ALI)是指由心源性以外的各种肺内、外致病因素导致的急性进行性呼吸衰竭。肺内过度和失控的炎症反应起关键作用,以肺血......
Objective To detect the expression of vascular endothelial growth factor C(VEGF-C)/VEGFR-3 in cervical cancer by tissue ......
Inhibition of VEGFR-2 signaling pathway has already become one of the most promising approaches for the treatment of can......
血管内皮生长因子受体(vascular endothelial growth factor receptors,VEGFRs)包括Flt-1(VEGFR1),KDR/Flk-1(VEGFR2)和Flt-4(VEG......
血管内皮生长因子受体-2(VEGFR-2)属于蛋白酪氨酸激酶受体超家族,对肿瘤转移和肿瘤血管生成具有重要调控作用。目前已有多个VEGFR-......
人程序性细胞死亡分子10(Homo sapiens programmed cell death 10,PDCD10),最初被称为TFAR15(TF-1 cell apoptosis related gene 1......
背景:已知循环内皮祖细胞(EPC)参与血管发生且在急性心肌梗死(AMI)后被动员。为了检验以下假设——EPC的血管生成功能会影响心肌梗......
A model of vascular endothelial cell membrane chromatography was established by using an ECV304 cell membrane stationary......
Streptozotocin induced diabetic retinopathy in rat and the expression of vascular endothelial growth
AIM:To establish the rat model of streptozotocin(STZ)induced diabetic retinopathy(DR),which is the most common cause of ......
研究目的:探讨血糖控制良好的2型糖尿病患者血管内皮生长因子-A(VEGF-A)及其受体VEGFR1和VEGFR2含量及其临床意义。研究方法:本文......
Hypertension,2009,54:652-658.阻断血管内皮生长因子(VEGF)信号传导通路的药物和抗体可以通过抑制肿瘤血管生成,改善多种肿瘤病人......
目的:研究2型糖尿病对外周动脉疾病患者血浆内的血管内皮生长因子(VEGF-A)及其水溶性受体(s VEGFR-1和s VEGFR-2)浓度的影响。创新......
除了血压的升高,自发性高血压大鼠(spontane-ously hypertensive rat,SHR)还有多种微血管并发症,包括内皮细胞凋亡和毛细血管稀疏......
目的探讨两条肿瘤靶向抑制肽(QKRKRKKSRKKH、RKRKRKKSRYIVLS)经化学修饰后(N端乙酰化、C端酰胺化)的稳定性,并初步探讨其作用靶点......
乳腺癌易伴发腋淋巴结转移的因素有肿瘤巨大 ,高分级 ,内分泌受体阴性 ,伴血管淋巴浸润 ,患者年龄 ,组织学类型 ,DNA倍性和 S相比......
VEGFR1/CXCR4-positive progenitor cells modulate local inflammation and augment tissue perfusion by a
Recruitment and retention of circulating progenitor cells at the site of injured or ischemic tissues facilitates adult n......
目的:研究外周动脉疾病(PAD)患者血浆中血管内皮生长因子A(VEGF-A)和它的可溶性1型和2型受体(sV EGFR-1和sV EGFR-2)的浓度与营养......
