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目的探讨碱性成纤维细胞生长因子(bFGF)在翼状胬肉的表达及手术方式对翼状胬肉手术后复发的影响。方法 98例初发型翼状胬肉患者(107眼)随机分成两组,50眼行翼状胬肉单纯切除术(单纯切除组),57眼行翼状胬肉切除联合角膜缘干细胞移植术(干细胞移植组);免疫组织化学SP法检测翼状胬状组织bFGF表达。结果 bFGF在翼状胬肉的表达明显高于正常结膜(P<0.01);干细胞移植术组术后复发率明显低于单纯切除术组(15.8%vs.28.0%)(P<0.01),且复发时间明显推迟[(13.6±4)个月vs.(7.4±2)个月](P<0.01);bFGF表达量高的患者手术后复发率明显高于表达量低的患者(24.6%vs.18.8%)(P<0.01)。结论 bFGF表达强度可作为预测手术后复发的危险因素;胬肉切除联合角膜缘干细胞移植术可降低术后复发率。
Objective To investigate the expression of basic fibroblast growth factor (bFGF) in the pterygium and the effect of surgical modality on the recurrence of pterygium surgery. Methods A total of 98 patients with primary pterygium (107 eyes) were randomly divided into two groups. Fifty eyes underwent pterygium excision (simple excision group) and 57 eyes underwent pterygium excision combined with limbal stem cell transplantation (stem cell transplantation group ); Immunohistochemical SP method was used to detect the expression of bFGF in the pterygium. Results The expression of bFGF in pterygium was significantly higher than that in normal conjunctiva (P <0.01). The recurrence rate of stem cell transplantation group was significantly lower than that of simple resection group (15.8% vs.28.0%, P <0.01) (13.6 ± 4) months vs. (7.4 ± 2) months] (P <0.01). The recurrence rate of patients with high bFGF expression was significantly higher than that of patients with low expression (24.6% vs. 18.8%) (P <0.01). Conclusions The expression of bFGF can be used as a predictor of postoperative recurrence. Pterygium resection combined with limbal stem cell transplantation can reduce the recurrence rate.