论文部分内容阅读
目的观察参蛤益肺胶囊对慢性阻塞性肺疾病(COPD)大鼠气道炎症因子及气道病理形态的影响。方法SD大鼠60只,随机分为正常对照组、COPD模型组、金水宝对照组及参蛤益肺胶囊低、中、高剂量组,烟熏加脂多糖法造模,观察各组治疗后肺泡灌洗液(BALF)中白细胞介素8(IL-8)、肿瘤坏死因子α(TNF-α)水平及气道病理组织学变化。结果参蛤组IL-8、TNF-α水平比模型组减低(P<0.01),气道病理改变较轻。结论参蛤益肺胶囊具有一定的抑制COPD气道炎症的作用。
Objective To observe the effect of Shenqi Yifei Capsule on airway inflammation and airway pathology in rats with chronic obstructive pulmonary disease (COPD). Methods Sixty Sprague-Dawley rats were randomly divided into normal control group, COPD model group, Jinshuibao control group, and Shenqi Yifei Capsule low, middle and high dose groups. The smoking and lipopolysaccharide method was used to establish the model. Levels of interleukin-8 (IL-8), tumor necrosis factor-α (TNF-α) and airway histopathological changes in alveolar lavage fluid (BALF). Results The levels of IL-8 and TNF-α in the Shenqi group were lower than those in the model group (P<0.01), and the airway pathology was lighter. Conclusion Shenqi Yifei Capsule has a certain effect on inhibiting airway inflammation of COPD.