论文部分内容阅读
目的在口服降糖药不能良好控制血糖情况下,加用每日1次甘精胰岛素(来得时)或中效胰岛素(诺和灵N)联合二甲双胍治疗,比较这两种方案的疗效和不良事件。方法40例口服降糖药控制不良的2型糖尿病患者随机分为来得时+二甲双胍组(A组)和诺和灵N+二甲双胍组(B组),每组各20例,共观察3个月。比较2组治疗后空腹血糖(FPG)、餐后2h血糖(2hPG)、糖化血红蛋白(HbA1c)、胰岛素用量、低血糖出现次数及体重增加情况。结果A组FPG﹑2hPG﹑HbA1c水平及出现低血糖次数﹑体重增加值均低于B组(P<0.01),平均来得时使用剂量大于诺和灵N。结论口服降糖药疗效差的2型糖尿病患者应用来得时联合二甲双胍治疗,有更显著、安全的降糖效果。
OBJECTIVE To compare the efficacy and adverse events of both the two regimens with oral glargine plus propofol once daily (nocturnal) or metformin combined with metformin when the oral hypoglycemic agents do not control blood sugar well. . Methods Forty cases of type 2 diabetes patients with poorly controlled oral hypoglycemic agents were randomly divided into two groups: metformin group (group A) and norepinephrine N + metformin group (group B), with 20 cases in each group for 3 months. Fasting blood glucose (FPG), postprandial 2h blood glucose (2hPG), HbA1c, insulin dosage, frequency of hypoglycemia and weight gain were compared between the two groups. Results The levels of FPG, 2hPG, HbA1c and the frequency of hypoglycemia and weight gain in group A were lower than those in group B (P <0.01). Conclusion Oral hypoglycemic agents in patients with type 2 diabetes mellitus should be treated with metformin and metformin, with a more significant and safe hypoglycemic effect.