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目的:探讨E-钙黏素(E-cadherin,E-cad)及增殖细胞核抗原(Proliferating Cell Nuclear Antigen,PCNA)在大肠癌中的表达与淋巴转移的关系。方法:应用免疫组化SP法检测52例大肠癌中E-cad、PCNA的表达情况。结果:52例大肠癌组织中E-cad、PCNA的阳性表达率分别为42.3%(22/52)、71.2%(37/52),PCNA的阳性率与淋巴转移呈正相关(P<0.05),而E-cad的表达则与淋巴转移呈负相关,差异有显著性(P<0.05)。结论:PCNA在大肠癌中的过度表达及E-cad的下调表达在大肠癌的发生、发展中可能协同起作用,并可作为判断大肠癌生物学行为的指标。
Objective: To investigate the relationship between the expression of E-cadherin (E-cad) and Proliferating Cell Nuclear Antigen (PCNA) in colorectal carcinoma and lymphatic metastasis. Methods: Immunohistochemical SP method was used to detect the expression of E-cad and PCNA in 52 cases of colorectal cancer. Results: The positive rates of E-cad and PCNA in 52 cases of colorectal cancer were 42.3% (22/52) and 71.2% (37/52), respectively. The positive rate of PCNA was positively correlated with lymphatic metastasis (P <0.05) However, the expression of E-cad was negatively correlated with lymphatic metastasis (P <0.05). Conclusion: The overexpression of PCNA in colorectal cancer and the down-regulation of E-cad may play a synergistic role in the occurrence and development of colorectal cancer, and may be used as an index to judge the biological behavior of colorectal cancer.