越来越多的疾病例如:血液系统肿瘤、再生障碍性贫血、某些实体瘤和免疫缺损病,需要用骨髓移植进行治疗,但移植物抗宿主病(GVHD)是骨髓移植的主要障碍,即使主要组织相客性抗原相匹配的供体,也会引起一定比例GVHD。大量研究证明供体骨髓中的T细胞是引起GVHD的主要原因,去除供体骨髓中的T细胞就有可能预防或减轻GVHD。各种去除 A growing number of diseases such as hematologic tumors, aplastic anemia, certain solid tumors and immunodeficiency diseases require treatment with bone marrow transplantation, but graft versus host disease (GVHD) is a major obstacle to bone marrow transplantation even if Donors whose major histocompatible guest antigen matches also cause a certain proportion of GVHD. Numerous studies have demonstrated that T cells in the donor’s bone marrow are the major cause of GVHD and that it is possible to prevent or reduce GVHD by removing T cells from the donor’s bone marrow. Various removal