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早产(preterm birth,PTB)是围产儿死亡率和新生儿远期患病率最重要的因素,对家庭、社会带来重大的经济负担,使其成为一个全球性的卫生问题。如何有效预测早产是对其进行有效干预的前提,当今公认的早产预测方法有胎儿纤维连接蛋白浓度和经阴道超声测量宫颈长度,但其临床运用均存在一定局限性。由于涉及到母婴安全问题,确认一种更加高效、微创、稳定的早产预测方法是产科研究的当务之急。随着对松弛素(relaxin,RLX)研究的深入,已证明血清松弛素(serum relaxin,SRLX)可作为早产的预测指标之一,现将二者关系的研究进展综述如下。
Preterm birth (PTB) is the most important factor in the perinatal mortality and the prevalence of newborn infants. It has a significant financial burden on families and society, making it a global health issue. How to effectively predict preterm birth is a prerequisite for its effective intervention. Today’s predictive methods for preterm birth are fetal fibronectin concentration and transvaginal ultrasound to measure the length of the cervix, but there are some limitations in clinical application. Due to the issue of maternal and child safety, identifying a more efficient, minimally invasive and stable prediction of preterm birth is a top priority for obstetric research. With the further study on relaxin (RLX), serum relaxin (SRLX) has been proved as one of the predictors of preterm delivery. The progress of the research on the relationship between them is summarized as follows.