在文献回顾的基础上,分析神经精神狼疮的临床表现、病理生理机制、诊断、治疗及预后。临床上,脑脊液、脑电图及脑影像学检查可提高本病诊断的敏感性,较大剂量的激素、免疫抑制剂及抗凝治疗,尤其是对合并症的处理仍是本病治疗的关键。但是,由于本病的临床多样性,如何维持其长期临床缓解,特别是提高生存质量,仍是今后重点需要解决的难题。 Based on the literature review, we analyzed the clinical manifestations, pathophysiological mechanisms, diagnosis, treatment and prognosis of neuroleptic lupus. Clinically, cerebrospinal fluid, electroencephalogram and brain imaging examination can improve the sensitivity of the diagnosis of the disease, the higher the dose of hormones, immunosuppressive agents and anticoagulant therapy, especially for the treatment of complications is still the key to the treatment of this disease . However, due to the clinical diversity of the disease, how to maintain its long-term clinical remission, especially improving the quality of life, remains the key problem to be solved in the future.