早在1880年就有报告,进行性的慢性肝疾患有时可伴有发绀和杵状指等呼吸机能低下的体征,1950年弄清了该病病理机制是动脉血氧饱和度降低,指出该病特点是坐位或立位比卧位更易发生低氧血症,作为体征的蜘蛛痣,与此症状有关。最近,随着呼吸机能检查方法的进步和肝移植的普及,肝功障碍时的低氧血症又重新被重视起来。 As early as 1880, it has been reported that progressive chronic liver disease may sometimes be accompanied by signs of hypopnea such as cyanosis and clubbing. In 1950, it was clarified that the pathological mechanism of the disease is a decrease in arterial oxygen saturation, pointing out that the disease Is characterized by sitting or standing position more prone to hypoxemia than lying, as a sign of spider nevus, and the symptoms. Recently, hypoxemia during liver dysfunction has been re-emphasized with the progress of respiratory function tests and the popularity of liver transplantation.