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二乙基亚硝胺（ＤＥＮ）诱发大鼠肝癌过程中，可使肝中增殖指标γ－谷氨酰转肽酶（γ－ＧＴ），谷胱甘肽Ｓ－转移酶（ＧＳＴ），胞液和膜性酪氨酸蛋白激酶（ｃ－ＴＰＫ，ｍ－ＴＰＫ）有不同程度的逐步升高，直至１６周（除ｃ－ＴＰＫ在第１２周活力最高外），而分化指标精氨酸酶（ＡＧＮ）则明显降低，如在诱癌开始的同时给予全反式维甲酸（ＲＡ）连续１６周则可延缓γ－ＧＴ、ＧＳＴ和两种ＴＰＫ的升高和ＡＧＮ的降低，这种作用并非ＲＡ本身对酶活力的影响，而是ＲＡ阻断肝癌发展的结果。
During the process of rat liver cancer induced by diethylnitrosamine (DEN), it can increase the liver proliferation index γ-glutamyl transpeptidase (γ-GT), glutathione S-transferase (GST), cytosol Membranous tyrosine protein kinases (c-TPK, m-TPK) increased gradually to varying degrees until 16 weeks (except that c-TPK had the highest activity in the 12th week), while the differentiation marker arginase ( AGN) is significantly reduced, such as the beginning of the induction of cancer while giving all-trans retinoic acid (RA) for 16 consecutive weeks can delay the increase of γ-GT, GST, and both TPK and AGN, this effect is not RA The effect of itself on enzyme activity, but the result of RA blocking the development of liver cancer.