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对39例初发和复发单纯性肾病综合征病儿外周血T细胞亚群,IgG,IgA,IgM进行检测.结果表明,无论初发或复发病例外周血中CD_3~+和CD_4~+细胞水平无明显变化,CD_8~+和CD_(10)~+细胞均明显高于对照组,CD_4~+/CD_8~+细胞比值均明显低于对照组,而初发组和复发组间无明显差异;85.3%的病儿伴血清IgG降低,29.4%的病儿伴血清IgM增高,CD_4~+/CD_8~+细胞比值与血清IgG水平呈显著正相关,而与IgM水平呈明显负相关.提示单纯性肾病综合征病儿存在T细胞功能紊乱,且与病儿体液免疫功能紊乱的关系密切.
T cell subsets, IgG, IgA and IgM in peripheral blood of 39 newly diagnosed and recurrent simple nephrotic syndrome patients were detected.The results showed that the level of CD_3 ~ + and CD_4 ~ + There was no significant difference between the two groups (P> 0.05). CD_8 ~ + and CD_ (10) ~ + cells were significantly higher than that of the control group, and the ratio of CD_4 ~ + / CD_8 ~ + cells was significantly lower than that of the control group Serum IgG was decreased in 85.3% of sick children and IgM in 29.4% of sick children, the ratio of CD_4 ~ + / CD_8 ~ + cells was positively correlated with serum IgG level, but negatively correlated with IgM level Nephrotic syndrome in children with T cell dysfunction, and sick children with humoral immune dysfunction is closely related.