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目的:研究糙苏根的化学成分。方法:用硅胶柱色谱、凝胶柱色谱等多种柱色谱分离,制备高效液相色谱纯化,得到单体化合物,用各种有机波谱鉴定化合物结构。结果:分离得到13个化合物,鉴定为齐墩果酸(oleanolic acid,1),2α-羟基乌苏酸(corosolic acid,2),3β,23-二羟基-12-烯-28-齐墩果酸(hederagenin,3),2α,3β,23-三羟基-12-烯-28-齐墩果酸(arjunolicacid,4),2α,3β,23,24-四羟基-12-烯-28-齐墩果酸(belleric acid,5),3β-hydroxy-29-al-12-en-28-oleanoic acid(6),butyrospermol(7),β-谷甾醇(β-sitosterol,8),β-胡萝卜苷(daucosterol,9),咖啡酸(caffeic acid,10),3-甲氧基-4-羟基-苯甲酸(vanillic acid,11),对羟基苯甲酸(p-hydroxy-benzoic acid,12),3,4-二羟基-苯甲酸(3,4-dihydroxy-benzoic acid,13)。结论:化合物3～9,11～13为首次从糙苏中分离得到的化合物。
Objective: To study the chemical constituents of Prunus salicina. Methods: The compounds were purified by high performance liquid chromatography (HPLC) using silica gel column chromatography and column chromatography. The compounds were identified by various organic spectra. Results: Thirteen compounds were isolated and identified as oleanolic acid (1), 2α-hydroxyrostanoate (corosolic acid, 2), 3β, 23-dihydroxy-12-ene-28, Oleanolic acid Acids (hederagenin, 3), 2α, 3β, 23-trihydroxy-12-ene-28-arjunolic acid (4), 2α, 3β, 23,24-tetrahydroxy-12-ene-28- Berberic acid (5), 3β-hydroxy-29-al-12-en-28-oleanoic acid (6), butyrospermol (7), β-sitosterol (8), β-carrot Daucosterol (9), caffeic acid (10), 3-methoxy-4-hydroxy-benzoic acid (11), p-hydroxy-benzoic acid (12), 3,4-dihydroxy-benzoic acid (13). CONCLUSION: Compounds 3-9, 11-13 are the compounds isolated from the rough cortex for the first time.