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目的 探讨纤维连接蛋白(FN)在多器官功能不全综合征(MODS)中的表达规律及其意义。方法 应用免疫组化技术,对20例MODS和12例非MODS死亡标本的心、肺、肾组织的FN进行检测。结果 非MODS的心、肺、肾组织FN表达多为阳性或强阳性,MODS多为弱阳性或阳性;两组间比较,差异显著(P<0.01)。结论 MODS时组织中FN降低,FN降低可能导致MODS。
Objective To investigate the expression of fibronectin (FN) in multiple organ dysfunction syndrome (MODS) and its significance. Methods Immunohistochemistry was used to detect FN in heart, lung and kidney of 20 MODS and 12 non-MODS death specimens. Results The expression of FN in heart, lung and kidney of non-MODS patients was mostly positive or strongly positive, while MODS was mostly weakly positive or positive. There was significant difference between the two groups (P <0.01). Conclusions The decrease of FN in MODS and the decrease of FN may lead to MODS.