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山莨菪碱(Anisodamine,654-2)是茄科植物山莨菪(Anisodus tangticus(Max)Pasch)中分离出的一种生物碱,它是我国科研人员首先研制的一种抗胆碱药,临床用于抗休克有肯定的疗效。近年的研究报道654-2对缺血再灌注心肌损伤有一定的保护作用,并认为该作用与其抗钙和抗氧自由基的作用有关。654-2对哇巴因致心脏毒性影响的研究,未见文献报道,本实验以钙拮抗剂异搏定(Verapamil,Ver)为对照药,探讨654-2对哇巴因致豚鼠心律失常的影响。
Anisodamine (654-2) is an alkaloid isolated from Anisodus tangticus (Max) Pasch. It is an anticholinergic first developed by Chinese researchers and is used clinically in anti-shock Have a positive effect. Recent studies have reported that 654-2 has a protective effect on myocardial ischemia-reperfusion injury, and that the role of anti-calcium and antioxidant free radical role. 654-2 on ouabain induced cardiotoxicity of the study has not been reported in the literature, this experiment with calcium antagonist verapamil (Verapamil, Ver) as a control drug to investigate the ouabain induced guinea pig arrhythmia influences.