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目的研究养心氏片(YXS)对环孢素A(CsA)血药浓度及其药动学参数的影响。方法采用反相高效液相色谱法(RP-HPLC)对单用CsA及YXS与CsA合用后家兔体内CsA全血浓度进行测定,并对两组药动学参数进行统计学处理。结果YXS可使CsA的Cmax增大、T1/2β减小,差异有显著性(P<0.05),其余药动学参数无显著变化。结论养心氏片可使CsA的峰浓度增高、消除速率加快。
Objective To investigate the effect of Yangxinshi (YXS) on the plasma concentration of cyclosporine A (CsA) and its pharmacokinetic parameters. Methods RP-HPLC was used to determine the concentration of CsA in rabbits after CsA and YXS combined with CsA. The pharmacokinetic parameters of the two groups were statistically analyzed. Results YXS could increase the Cmax and T1/2β of CsA, and the difference was significant (P<0.05). There was no significant change in other pharmacokinetic parameters. Conclusion Yangxin’s tablet can increase the peak concentration of CsA and accelerate the elimination rate.