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为考察以热聚合法取代紫外辐照法在较高浓度下制备稳定的脂肪酸囊泡的可行性,以可聚合单体共轭亚油酸(CLA)及其钠盐混合物为原料,在水溶液中经p H响应自组装得到共轭亚油酸囊泡(CLA-Ufasome),再通过热聚合法对高浓度CLA-Ufasome自交联进行化学绑定,制备稳定的自交联共轭亚油酸囊泡(CLA-FAV),并采用透射电子显微镜(TEM)和动态激光光散射(DLS)对其进行表征。结果表明,在p H=8.6的条件下,在3~100mmol/L〔cvc(CLA)的500倍〕的浓度范围内均得到粒径为10~20 nm的CLA-FAV。说明经简单的热聚合法制备的CLA-FAV形貌与紫外法基本一致;该热聚合法CLA-FAV对5-氟尿嘧啶(5-FU)具有良好的包载缓释效果。
In order to investigate the feasibility of preparing stable fatty acid vesicles by thermal polymerization instead of UV irradiation at higher concentration, CLA and its sodium salt mixture were used as raw materials in aqueous solution The conjugated linoleic acid vesicles (CLA-Ufasome) were self-assembled by p H response, and then the high concentration CLA-Ufasome self-crosslinking was chemically bound by thermal polymerization to prepare stable self-crosslinking conjugated linoleic acid The vesicles (CLA-FAV) were characterized and characterized by transmission electron microscopy (TEM) and dynamic laser light scattering (DLS). The results showed that the CLA-FAV with the particle size of 10-20 nm was obtained in the concentration range of 3 ~ 100 mmol / L [500 times of cvc (CLA)] under the condition of p H = 8.6. The results showed that the morphology of CLA-FAV prepared by simple thermal polymerization was basically the same as that of UV. The CLA-FAV had a good sustained-release effect on 5-fluorouracil (5-FU).