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目的 观察心肌及传导组织内肌动蛋白、血浆白蛋白及纤维连接蛋白的染色变化，探讨青壮年猝死综合征(SMDS)死后诊断的新方法。方法 应用免疫组化S-P法，对SMDS及冠心病猝死者心肌及传导系统内肌动蛋白、血浆白蛋白和纤维连接蛋白的进行染色观察。结果 22例SMDS例猝死者心肌及传导系统内的肌动蛋白缺染17例；血浆白蛋白染色阳性18例；纤维连接蛋白染色阳性15例。并发现在SMDS中，8例有CCS严重病变。结论 心肌及传导系统内血浆蛋白、肌动蛋白改变与SMDS密切相关，部分SMDS病例死前存在早期心肌缺血或梗死的改变。
Objective To observe the changes of actin, plasma albumin and fibronectin in myocardium and conduction tissue and to explore a new method for the diagnosis of sudden death syndrome (SMDS) in young adults. Methods Immunohistochemical S-P method was used to observe the actin, plasma albumin and fibronectin in myocardium and conduction system of sudden death of SMDS and coronary heart disease. Results In the 22 cases of sudden death from SMDS, 17 cases were found with actin deficiency in myocardium and conduction system, 18 cases were positive for plasma albumin staining and 15 cases were positive for fibronectin staining. And found in the SMDS, 8 cases of CCS severe disease. Conclusions The changes of plasma protein and actin in myocardium and conduction system are closely related to SMDS. Some patients with SMDS have early changes of myocardial ischemia or infarction.