系统并发症主要发生于类风湿因子阳性的患者和有严重关节疾病的患者。内脏类风湿小结(肉芽肿) 类风湿小结可侵犯内脏器官。最常累及肺部,男性多见,尤其吸烟或患慢性支气管炎的患者。肺部小结可增大,中心形成空洞。这种空洞性小结可穿破胸膜,引起支气管胸膜瘘和脓胸,威胁生命。小结往往累及主动脉瓣或二尖瓣,引起严重瓣膜疾病。小结亦可发生于心肌中,小结发生于心脏隔壁时可引起心律失常。肉芽肿尚可累及主动脉根部或大冠状动脉,可发生心肌梗塞,引起死亡。其他较罕见的内脏肉芽肿可发生于软脑膜或椎管,其症状如占位性病变。类风湿性脉管炎类风湿性关节炎的最显著和致命的系统并发症是大血管脉管炎,其表现类似结节性多动脉炎。在脉管炎病变内可见补体和免疫球蛋白, Systemic complications mainly occur in rheumatoid factor-positive patients and patients with severe joint disease. Visceral rheumatoid nodules (granulomas) rheumatoid nodules can invade internal organs. Most often involve the lungs, men more common, especially smoking or suffering from chronic bronchitis patients. Pulmonary nodules can increase, the center of the formation of holes. This empty summary can pierce the pleura, causing bronchopleural fistula and empyema, life-threatening. Summary Often involving the aortic valve or mitral valve, causing serious valve disease. Summary can also occur in the myocardium, the summary occurs in the heart next door can cause arrhythmia. Granulomatous can still involve the aortic root or large coronary artery, myocardial infarction may occur, causing death. Other rare visceral granulomas can occur in the pia mater or spinal canal, with symptoms such as space-borne lesions. Rheumatoid Vasculitis The most significant and fatal systemic complication of rheumatoid arthritis is macrovascular vasculitis, which behaves like polyarteritis nodosa. In the vasculitis lesions can be seen complement and immunoglobulin,