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目的 观察诺维本和紫杉醇为主的联合方案治疗非小细胞肺癌近期疗效与毒副反应。方法 1995年 6月～ 1998年 8月本院收治的晚期非小细胞肺癌 5 2例 ,随机分两组进行观察。 结果 诺维本加顺铂有效率达 42 % ,紫杉醇加卡铂有效率达 38.4% ,相比疗效无显著差别 (P>0 .0 5 ) ;毒副反应主要为胃肠道反应和骨髓抑制 ,紫杉醇加卡铂要比诺维本加顺铂轻 (P<0 .0 1)。 结论 诺维本加顺铂方案治疗非小细胞肺癌疗效略高于紫杉醇加卡铂 ,但毒副反应要高于紫杉醇加卡铂组。
Objective To observe the short-term curative effect and toxicity of non-small cell lung cancer (NSCLC) treated with combination of nocitin and paclitaxel. Methods From June 1995 to August 1998, 52 cases of advanced non-small cell lung cancer admitted to our hospital were randomly divided into two groups. Results The efficacies of nociceptin plus cisplatin were 42%, and the effective rate of paclitaxel plus carboplatin was 38.4% (P> 0.05). The main side effects were gastrointestinal reaction and myelosuppression , Paclitaxel plus carboplatin compared with novibenzadine and cisplatin (P <0.01). Conclusions Noviben plus cisplatin regimen is more effective than paclitaxel and carboplatin in the treatment of non-small cell lung cancer, but the toxicity is higher than paclitaxel plus carboplatin.