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采用ELISA法检测了脏器衰竭患儿36例，健康儿20例血清磷脂酶A2（PLA2）及肿瘤坏死因子（TNF－α）含量，并监测病儿脏器功能及动脉血气，探讨血清PLA2及TNF－α在多脏器衰竭（MOF）发生、发展中的作用及意义。结果：血清PLA2及TNF－α含量在MOF组明显高于单衰组，死亡组显著高于治愈组（P＜0.05）；PLA2与TNF－α、动脉血氧分压呈相关关系。提示：PLA2及TNF－α参与了MOF病理过程，动态监测血清PLA2及TNF－α对MOF判断及预后评估等均有指导性的临床意义。
The levels of serum PLA2 and TNF-α in 36 children with organ failure and 20 healthy children were measured by ELISA. The organ function and arterial blood gas were monitored. The serum PLA2 and The role and significance of TNF-α in the occurrence and development of multiple organ failure (MOF). Results: The levels of PLA2 and TNF-α in serum were significantly higher in the MOF group than those in the single failure group, and were significantly higher in the death group than in the control group (P <0.05). PLA2 was correlated with TNF-α and arterial partial pressure of oxygen. It is indicated that PLA2 and TNF-α are involved in the pathological process of MOF. Dynamic monitoring of serum PLA2 and TNF-α has guiding clinical significance in judging MOF and prognosis.