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胰腺癌是具有高度侵袭性的恶性肿瘤之一,目前在胰腺癌的手术治疗及放化疗方面虽已取得明显进展,但胰腺癌患者术后5a生存率仍较低,因此寻找胰腺癌新的靶向治疗方法至关重要。四次跨膜蛋白-1是四次跨膜蛋白家族的重要成员之一,其在多种肿瘤组织中高表达,而在正常组织中低表达,且该基因与肿瘤细胞侵袭、迁移和血管生成等多种功能密切相关,近年已作为恶性肿瘤治疗的新靶点被广泛研究。本文就四次跨膜蛋白-1与胰腺癌的研究进展作一综述。
Pancreatic cancer is one of the highly aggressive malignant tumors. Although there have been significant advances in the surgical treatment and chemoradiation of pancreatic cancer, the survival rate of pancreatic cancer remains low after 5 years, so the new target for pancreatic cancer To the treatment is essential. Tetrameric transmembrane protein-1 is an important member of the four-transmembrane protein family, which is highly expressed in many tumor tissues but low in normal tissues, and is associated with tumor cell invasion, migration and angiogenesis A variety of functions are closely related, in recent years as a new target for the treatment of malignant tumors has been extensively studied. This review summarizes the progress of transmembrane protein-1 and pancreatic cancer.