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This study was designed to evaluate the effect of estrogen on thegrowth of leiomyomas and the mechanism of testosterone propionate action on thetumor.The levels of estrogen receptors in uterine tissues and of estradiol andprogesterone in uterine tissues and plasma were determined in 47 women withleiomyoma.The levels of estrogen receptor and estradiol in leiomyomatous tissueswere 37.6±4.0 fmol/mg protein and 401.7±92.6 pg/g tissue respectively.Both ofthem were higher than the corresponding values in normal uterine tissues(P<0.05).The concentration of estrogen receptor in the leiomyomas of 11 patientstreated with testosterone propionate was 18.9±9.4 fmol/mg protein,significantlylower than that of the untreated group(P<0.05).It is suggested that the changesof the levels of estrogen receptor and estradiol in the leiomyomatous tissues berelated to the growth of the tumor and one of the ways for testosterone propionateto inhibit the growth of leiomyomas might be due to the suppression of theestrogen receptor content in leiomyomas.
This study was designed to evaluate the effect of estrogen on the growth of leiomyomas and the mechanism of testosterone propionate action on the tumor. The levels of estrogen receptors in uterine tissues and of estradiol and progesterone in uterine tissues and plasma were determined in 47 women with leiomyoma. of estrogen receptor and estradiol in leiomyomatous tissueswere 37.6 ± 4.0 fmol / mg protein and 401.7 ± 92.6 pg / g tissue respectively.Both ofthem were higher than the corresponding values in normal uterine tissues (P <0.05). The concentration of estrogen receptor in the leiomyomas of 11 patient with withosterone propionate was 18.9 ± 9.4 fmol / mg protein, significantly lower than those of the untreated group (P <0.05) .It is suggested that the changes of the levels of estrogen receptor and estradiol in the leiomyomatous tissues berelated to the growth of the tumor and one of the ways for testosterone propionateto inhibit the growth of leiomyomas might be due to the suppression of theestrogen receptor content in leiomyomas.