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5硝基2氨基苯甲腈与环己酮反应可以按不同的反应机理得到7硝基他克林和2H3,1苯并噁嗪衍生物。研究了不同条件下生成二者的竞争反应工艺条件及反应机理,发现用三氯化铝作催化剂时,产物以7硝基他克林为主;改用无水氯化锌作催化剂时,产物以2H3,1苯并噁嗪衍生物为主。前者的生成是动力学控制,后者的生成是热力学控制。
Nitro 2 aminobenzonitrile and cyclohexanone reaction can be based on different reaction mechanism 7 nitro tacrine and 2H3,1 benzoxazine derivatives. The competitive reaction conditions and reaction mechanism were studied under different conditions. It was found that when aluminum trichloride was used as catalyst, the product was mainly 7-nitro-tacrine. When anhydrous zinc chloride was used as catalyst, the product 2H3,1 benzoxazine derivatives based. The former is generated by kinetic control and the latter by thermodynamic control.