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利用免疫组织化学方法检测了乳腺癌 CEA与 p5 3和 nm2 3- H1蛋白的表达 ,对其相关性进行了研究 ,同时与其它病理指标亦进行了比较。结果 :82例乳腺癌中 ,CEA阳性者 6 7例 (82 % ) ,与 p5 3蛋白的表达呈显著的负相关 (P<0 .0 5 ,而与 nm2 3- H1蛋白的表达则呈显著的正相关 (P<0 .0 5 ) ;同时 ,CEA的表达与肿瘤的病理分级和体积显著相关 (P <0 .0 5 ) ,即分级越高或肿瘤越大 ,CEA阳性表达率越低 ;而与患者年龄、淋巴结转移和肿瘤坏死程度无关 (P>0 .0 5 )。综合分析推测 :CEA可能是乳腺癌一种高分化肿瘤标志 ,并与肿瘤的浸润转移潜能有一定的关系 ,与其它指标联合应用在判断乳腺癌预后中有一定的价值。
Immunohistochemistry was used to detect the expression of CEA, p5 3 and nm2 3-H1 proteins in breast cancer. The correlations were also studied, and other pathological parameters were also compared. Results: In 82 cases of breast cancer, 67 (82%) were positive for CEA and negatively correlated with the expression of p5 3 protein (P <0.05), while the expression of nm23-H1 protein was significantly (P <0.05). At the same time, the expression of CEA was significantly correlated with the pathological grade and volume (P <0.05), ie, the higher the grade or the higher the tumor, the lower the CEA positive rate , But not with age, lymph node metastasis and the degree of tumor necrosis (P> 0.05) .According to the results of comprehensive analysis, CEA may be a well-differentiated tumor marker of breast cancer and has a certain relationship with the invasion and metastasis potential of tumor, Combined with other indicators in judging the prognosis of breast cancer have a certain value.