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目的：进一步阐明躯体传入冲动抑制中枢性升压反应的中枢递质机制。方法：用氯醛糖-脲酯混合麻醉、切断迷走神经的健康雄性家兔，侧脑室注射印防己毒（Picrotoxin）或中脑中央灰质（PAG）微量注射印防己毒，观察腓深神经（DPN）抑制电刺激下丘脑背内侧核（DMH）引起的中枢性升压反应的改变。结果：注药后DPN对DMH兴奋引起的升压反应的抑制作用削弱。结论：γ-氨基丁酸（GABA）受体参与了DPN抑制DMH兴奋诱发的升压反应，PAG是GABA受体在刺激DPN抑制DMH兴奋诱发的升压反应作用中的一个重要位点所在区。
OBJECTIVE: To further elucidate the central neurotransmitter mechanism of somatosensory impulse inhibiting central vasopressor response. Methods: Healthy male rabbits with vagus nerve were anesthetized with chloralose-urea ester and picrotoxin or PAG was injected intracerebroventricularly. The deep peroneal nerve (DPN) Inhibition of central stimulation of hypothalamic dorsal medial nucleus (DMH) induced by electrical stimulation. Results: The inhibitory effect of DPN on the antihypertensive response induced by DMH was weakened. CONCLUSION: GABA receptors are involved in the antihypertensive response induced by DPN in DMH excited rats. PAG is an important site of GABA receptor in stimulating DPN inhibition induced by DMH.