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目的探讨近年来葡萄胎的临床病理的特点,为临床治疗提供理论依据。方法回顾性分析1993年1月~2012年12月该院收治的葡萄胎患者447例的临床资料,分别与北京协和医院于1948~1975年和1989~2006年收治的葡萄胎的相关数据进行比较,并进行统计学分析。结果 447例患者的发病年龄15~55岁,平均29.41岁,平均停经时间77.7天(11周)。447例患者中,完全性葡萄胎342例(76.51%),部分性葡萄胎105例(23.49%)。与北京协和医院1948~1975年和1989~2006年收治的葡萄胎的临床资料比较,近年来葡萄胎的诊断时间提前,停经后阴道出血仍是患者就诊的主要原因,但发生率明显下降;妊娠期高血压疾病、妊娠剧吐、咯血等并发症的发生率降低,差异均有统计学意义(P<0.05)。恶变率升高,但差异无统计学意义(P>0.05)。结论近年来葡萄胎的诊断时间提前,临床表现发生了变化,临床工作中应予以重视。
Objective To investigate the clinicopathological features of hydatidiform mole in recent years and provide a theoretical basis for clinical treatment. Methods The clinical data of 447 cases of hydatidiform mole admitted from January 1993 to December 2012 in our hospital were retrospectively analyzed. The data of hydatidiform mole in Beijing Union Medical College Hospital from 1948 to 1975 and from 1989 to 2006 were compared respectively , And statistical analysis. Results The onset age of 447 patients was 15-55 years (average 29.41 years) with an average of 77.7 days (11 weeks) of menopause. Of the 447 patients, 342 (76.51%) had complete hydatidiform mole and 105 (23.49%) had partial hydatidiform mole. Compared with the clinical data of hydatidiform moles in Peking Union Medical College hospital from 1948 to 1975 and from 1989 to 2006, the diagnostic time of hydatidiform moles in advance was earlier than that of hydatidiform moles in Beijing Union Medical College Hospital. The vaginal bleeding after menopause was still the main cause of patients’ treatment, but the incidence was significantly decreased. Pregnancy Hypertensive disease, hyperemesis gravidarum, hemoptysis and other complications decreased, the differences were statistically significant (P <0.05). Malignant rate increased, but the difference was not statistically significant (P> 0.05). Conclusion In recent years, hydatidiform mole diagnosis time ahead of time, clinical manifestations have changed, clinical work should be taken seriously.