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目的:探讨川芎嗪单独给药、不同配伍给药在大鼠体内的代谢动力学规律。方法:32只SD大鼠,分为川芎嗪(30 mg.kg-1)组、川芎嗪+阿魏酸(30 mg.kg-1+50 mg.kg-1)组、川芎嗪+延胡索乙素(30 mg.kg-1+20 mg.kg-1)组、川芎嗪+阿魏酸+延胡索乙素(30 mg.kg-1+50 mg.kg-1+20 mg.kg-1)组,灌胃给药,采用高效液相色谱法测定各组大鼠血浆中川芎嗪的浓度,DAS 2.0程序计算药代动力学参数。结果:川芎嗪与阿魏酸配伍时,药时曲线下面积AUC0-t、达峰浓度Cmax和达峰时间Tmax与川芎嗪单独给药相比没有显著差异,但半衰期t1/2和平均驻留时间MRT0-t显著比川芎嗪单独给药时延长(P<0.05);川芎嗪与延胡索乙素配伍,及与阿魏酸、延胡索乙素同时配伍时AUC0-t,Cmax,Tmax与川芎嗪单独给药相比显著增大(P<0.05),而t1/2,MRT0-t与川芎嗪单独给药时相比无显著异。结论:阿魏酸可以延长川芎嗪在大鼠体内的作用时间,延胡索乙素能加快并增加川芎嗪在大鼠体内的吸收。
Objective: To investigate the pharmacokinetics of tetramethylpyrazine alone and different compatibility in rats. Methods: Thirty-two SD rats were divided into three groups: ligustrazine (30 mg.kg-1), ligustrazine + ferulic acid (30 mg.kg-1 +50 mg.kg-1) (30 mg.kg-1 + 20 mg.kg-1), ligustrazine + Group, intragastric administration, the concentration of ligustrazine in the plasma of each group was determined by high performance liquid chromatography, and the pharmacokinetic parameters were calculated by DAS 2.0 program. Results: When tetramethylpyrazine was combined with ferulic acid, the area under curve AUC0-t, peak concentration Cmax and peak time Tmax were not significantly different from those of tetramethylpyrazine alone, but the half-life t1 / 2 and average residence time The time of MRT0-t was significantly longer than that of ligustrazine alone (P <0.05). When the combination of ligustrazine and tetrahydropalmatine and the combination of ferulic acid and tetrahydropalmatine, the AUC0-t, Cmax, Tmax and tetramethylpyrazine alone (P <0.05), while there was no significant difference between t1 / 2, MRT0-t and tetramethylpyrazine alone. CONCLUSION: Ferulic acid can prolong the action time of ligustrazine in rats. Tetrahydropalmatine can accelerate and increase the absorption of ligustrazine in rats.