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目的:探讨替勃龙联合高压氧治疗更年期综合征的临床效果。方法:将96例更年期综合征患者随机分为实验组(50例)和对照组(46例),实验组采取替勃龙联合高压氧治疗,对照组单独采用替勃龙治疗,疗程均为30天,治疗前后分别对两组患者进行Kupperman评分、焦虑自评量表(SAS)和抑郁自评量表(SDS)评分,放射免疫法检测血清雌二醇(E2)、促卵泡生成激素(FSH)和促黄体生成激素(LH)的水平。结果:两组患者治疗后Kupperman评分、SAS评分和SDS评分均低于治疗前,差异有统计学意义(P<0.05),且治疗后实验组各评分均低于对照组,差异有统计学意义(P<0.05)。治疗后两组患者血清E2水平均高于治疗前,血清FSH和LH水平则低于治疗前,差异均有统计学意义(P<0.05),且实验组血清E2上升程度以及FSH和LH下降程度均比对照组高,差异均有统计学意义(P<0.05)。结论:替勃龙联合高压氧治疗更年期综合征,可以有效改善患者血清相关激素水平,从而有效减轻更年期综合征症状,尤其是焦虑和抑郁症状,为更年期综合征拓展新的有效治疗途径,具有良好的社会效益。
Objective: To investigate the clinical effect of tibolone combined with hyperbaric oxygen in the treatment of climacteric syndrome. Methods: Ninety-six patients with menopausal syndrome were randomly divided into experimental group (n = 50) and control group (n = 46). Tiberol and hyperbaric oxygen were used in the experimental group and tibolone alone in the control group. The course of treatment was 30 Day, before and after treatment, Kupperman score, self-rating anxiety scale (SAS) and depression self-rating scale (SDS) were used to evaluate the two groups of patients. Serum estradiol (E2), follicle-stimulating hormone ) And luteinizing hormone (LH) levels. Results: The Kupperman score, SAS score and SDS score of the two groups after treatment were both lower than those before treatment (P <0.05), and the scores of the experimental group were lower than the control group after treatment, the difference was statistically significant (P <0.05). After treatment, serum E2 levels in both groups were higher than those before treatment, serum FSH and LH levels were lower than before treatment, the difference was statistically significant (P <0.05), and serum E2 levels and FSH and LH decreased Both higher than the control group, the difference was statistically significant (P <0.05). Conclusion: The treatment of menopausal syndrome by tibolone combined with hyperbaric oxygen can effectively improve the levels of serum relevant hormones in patients with menopausal syndrome, so as to effectively alleviate the symptoms of menopausal syndrome, especially anxiety and depression, and develop new and effective therapeutic approaches for climacteric syndrome with good Social benefits