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目的探讨降钙素原(PCT)、白细胞介素6(IL-6)和超敏C反应蛋白(hs-CRP)在新生儿感染性疾病早期诊断中的应用价值。方法对正常对照组36例、感染性疾病新生儿童60例,采用化学发光法测定血清中PCT与IL-6,用免疫比浊法测定血清中hs-CRP水平。结果感染组急性期PCT、IL-6和hs-CRP 3项检测指标分别为(3.62±2.55)μg/L、(28.8±10.5)ng/L和(14.8±2.9)mg/L,恢复期3项检测指标分别为(0.038±0.01)μg/L、(4.9±2.1)ng/L和(3.9±2.03)mg/L;对照组3项检测指标分别为(0.036±0.008)μg/L、(4.63±1.98)ng/L和(3.8±1.9)mg/L。感染组急性期3项指标明显高于其恢复期和对照组(P<0.01)。三者相比,PCT和hs-CRP的特异性高于IL-6,IL-6的敏感性高于PCT和hs-CRP(P<0.01)。结论 PCT、IL-6和hs-CRP动态检测对新生儿感染性疾病早期诊断及疗效判定具有一定价值。
Objective To investigate the value of procalcitonin (PCT), interleukin-6 (IL-6) and hs-CRP in the early diagnosis of neonatal infectious diseases. Methods 36 cases of normal control group and 60 cases of neonatal infectious disease were detected by chemiluminescence method. Serum PCT and IL-6 were detected by chemiluminescence method. Serum hs-CRP levels were measured by immunoturbidimetry. Results The detection indexes of PCT, IL-6 and hs-CRP in the acute infection group were (3.62 ± 2.55) μg / L, (28.8 ± 10.5) ng / L and (14.8 ± 2.9) mg / L, The detection indexes were (0.038 ± 0.01) μg / L, (4.9 ± 2.1) ng / L and (3.9 ± 2.03) mg / L respectively in the control group and (0.036 ± 0.008) μg / L in the control group 4.63 ± 1.98) ng / L and (3.8 ± 1.9) mg / L, respectively. In the acute phase of infection, three indexes were significantly higher than those in convalescence and control groups (P <0.01). The specificity of PCT and hs-CRP was higher than that of IL-6, and the sensitivity of IL-6 was higher than that of PCT and hs-CRP (P <0.01). Conclusion The dynamic detection of PCT, IL-6 and hs-CRP has some value in the early diagnosis and curative effect of neonatal infectious diseases.