以苯乙酮及其氟代衍生物和甲酰胺为原料,一步合成了4-苯基嘧啶和4-(氟代苯基)嘧啶,并新合成了4-(2,4-二氟苯基)嘧啶,其结构经元素分析和1HNMR表征。讨论了催化剂种类及其用量、反应温度、反应时间以及柱分离过程中洗脱剂的选择5个因素对合成产率的影响,并通过实验对合成条件进行了优化。 Using acetophenone, its fluorinated derivatives and formamide as starting materials, 4-phenylpyrimidine and 4- (fluorophenyl) pyrimidine were synthesized in one step and 4- (2,4-difluorophenyl ) Pyrimidine whose structure was characterized by elemental analysis and 1HNMR. The influences of the type and amount of catalyst, the reaction temperature, the reaction time and the choice of eluent in the column separation process on the yield were discussed. The synthesis conditions were optimized through experiments.