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本文对43例确诊为鼠伤寒的患儿,在急性期(部分恢复期)作了部分体液免疫和细胞免疫功能测定。结果:提示血清免疫球蛋白IgG62％正常,IgM85.5％正常,IgA76.2％低于正常值。淋巴细胞转化率急性期66.7％低于正常值,继发于病毒性肝炎、麻疹、营养不良、佝偻病、穷血时LBT降低更为突出。恢复期明显上升。根据上述结果,进一步讨论了几个问题:(1)鼠伤寒为胞内寄生菌,损伤机体的细胞免疫功能,原有细胞免疫功能低下的患儿更易感染鼠伤寒。(2)血清型IgA明显降低,可导致SIgA亦降低,使易感性增加。(3)讨论了抗菌素加免疫增强剂联合治疗,可缩短病程,促进痊愈。
In this paper, 43 cases of confirmed typhoid fever in children in the acute phase (partial recovery) made some humoral and cellular immune function tests. Results: The results suggested that serum immunoglobulin IgG62% was normal, IgM85.5% normal and IgA76.2% lower than normal. Lymphocyte transformation rate of 66.7% in acute phase was lower than normal, secondary to viral hepatitis, measles, malnutrition, rickets, poor blood LBT more prominent. Recovery period increased significantly. Based on the above results, several issues were further discussed: (1) S. typhimurium is an intracellular parasite that damages the cellular immune function of the organism, and the original immunocompromised children were more likely to be infected with typhoid fever. (2) Serum IgA was significantly lower, can lead to SIgA also decreased, so that increased susceptibility. (3) discussed the antibiotic plus immune enhancer combination therapy, can shorten the course of the disease and promote recovery.