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Ｄ１７Ｓ５ＶＮＴＲ定位于人类第１７号染色体的短臂１区３带，与Ｐ５３基因紧密连锁，在Ｍｉｌｅｒ—Ｄｉｃｋｅｒ综合征中发现有Ｄ１７Ｓ５ＶＮＴＲ的信息丢失。为了进一步了解此基因的功能，本文采用聚合酶链反应结合聚丙烯酰胺凝胶电泳的方法对膀胱移行细胞癌的Ｄ１７Ｓ５ＶＮＴＲ的遗传多态性进行了研究。结果显示：膀胱移行细胞癌中Ｄ１７Ｓ５ＶＮＴＲ位点的频率不符合Ｈａｒｄｙ—Ｗｅｉｂｅｒｇ平衡；且ＰＹＮＺ２２ＶＮＴＲ位点的频率分布与正常人群之间存在显著性差异，肿瘤中纯合子的频率高于正常人群。结果表明：Ｄ１７Ｓ５ＶＮＴＲ可作为膀胱癌基因诊断的一个有用指标。
D17S5VNTR is located in the short arm 1 region and 3 bands of human chromosome 17 and is closely linked to the P53 gene. The information of D17S5VNTR is found in Miler-Dicker syndrome. In order to further understand the function of this gene, the genetic polymorphism of D17S5VNTR in bladder transitional cell carcinoma was studied by polymerase chain reaction and polyacrylamide gel electrophoresis. The results showed that the frequency of D17S5VNTR site in bladder transitional cell carcinoma did not accord with Hardy-Weiberg equilibrium. The frequency distribution of PYNZ22VNTR site was significantly different from that in normal population. The frequency of homozygote in tumor was higher than that in normal population. The results show that: D17S5VNTR can be used as a useful indicator of bladder cancer gene diagnosis.