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目的:探讨中药天芝草胶囊对肿瘤细胞周期的影响。方法:S180荷瘤小鼠ig天芝草胶囊0.5,1.0,2.0 g.kg-1,阳性药组ip环磷酰胺0.02 g.kg-1d-1,连续7 d,流式细胞仪检测动物给药后肿瘤组织细胞周期变化情况。结果:天芝草胶囊可阻滞肿瘤细胞周期的进程,天芝草胶囊高剂量组Sub-G1期,G0/G1期比率由(2.26±0.11)%上升为(2.61±0.04)%,并伴有S期比率下降,由(17.05±0.10)%下降为(12.59±0.30)%。结论:天芝草胶囊可阻滞肿瘤细胞周期在G0/G1期,抑制肿瘤细胞的增殖。
Objective: To investigate the effect of Tianzhicao capsule on tumor cell cycle. Methods: S180 tumor-bearing mice ig Tianzhi Cao capsule 0.5,1.0,2.0 g.kg-1, the positive drug group ip cyclophosphamide 0.02 g.kg-1d-1, for 7 days, the flow cytometry animal test Post-tumor cell cycle changes. Results: Tianzhicao Capsule could block the progression of tumor cell cycle. The Sub-G1 phase, G0 / G1 phase increased from (2.26 ± 0.11)% to (2.61 ± 0.04)% in Tianzhi Cao capsule high dose group, The ratio decreased from (17.05 ± 0.10)% to (12.59 ± 0.30)%. Conclusion: Tianzhicao Capsule can block tumor cell cycle in G0 / G1 phase and inhibit tumor cell proliferation.