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目的:比较观察抗幽门螺杆菌抗体牛奶根除幽门螺杆菌的效果。方法:用4株幽门螺杆菌(1株为标准菌株,3株为本地流行菌株)免疫奶牛,制备出抗幽门螺杆菌抗体牛奶。本次试验共筛选148例患者,C-14呼气试验阳性的患者为72例,最后符合入选标准的为39例,将符合标准的患者随机分为试验组和对照组,分别为21例和18例,试验组饮用含特异性幽门螺杆菌抗体的牛奶,对照组饮用普通牛奶,连续饮用2个月后,观察结果。结果:试验组的21名对象中,9人C-14呼气试验转为阴性,10人降低。有效清除率达42.86%,而对照组未有清除,两组清除率有统计学意义(P=0.005,P<0.05)。结论:抗幽门螺杆菌抗体牛奶具有多克隆性和很高的效价,能够有效清除胃内幽门螺杆菌。
Objective: To compare the effect of anti-Helicobacter pylori antibody to Helicobacter pylori eradication. Methods: Four H. pylori strains (one strain was a standard strain and three strains were endemic strains) were immunized with anti-Helicobacter pylori antibody milk. A total of 148 patients were screened in this study, 72 patients were positive for C-14 breath test and 39 patients were finally eligible for inclusion. Patients who met the criteria were randomly divided into experimental group and control group, 21 cases and 18 cases, the experimental group drinking milk containing specific anti-Helicobacter pylori antibody, the control group drinking regular milk, drinking continuously for 2 months after the observation. Results: Of the 21 subjects in the test group, 9 were negative for the C-14 breath test and 10 were decreased. The effective clearance rate reached 42.86%, while the control group did not clear, the clearance rate was statistically significant (P = 0.005, P <0.05). Conclusion: The anti-Helicobacter pylori antibody polyclonal and high titer milk, can effectively remove the stomach of Helicobacter pylori.