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采用放射免疫法测定了20名对照者和32例脑梗塞患者急性期和恢复期脑脊液(CSF)、血浆中内皮素(ET)的含量。发现急性期血浆ET含量较对照组显著升高(P<0.001),并与梗塞灶大小呈正相关(r=0.5365,P<0.002),临床病情愈重血浆ET含量愈高,至恢复期仍未见下降的趋势。急性期和恢复期CSF中ET含量较对照组无显著差异(P均>0.05)。提示血浆ET含量升高与缺血性脑损伤有关。
The levels of endothelin (ET) in plasma and cerebrospinal fluid (CSF) in 20 controls and 32 patients with cerebral infarction were measured by radioimmunoassay. The level of plasma ET in acute stage was significantly higher than that in control group (P <0.001), and positively correlated with infarct size (r = 0.5365, P <0.002) See the downward trend. ET levels in acute and convalescent CSF were not significantly different from those in control group (all P> 0.05). Tip plasma ET levels and ischemic brain damage related.