为了探讨人蓝斑神经元的胚胎发育特征 ,为蓝斑 -脊髓移植选择适宜胎龄提供形态学根据 ,本研究用免疫组织化学技术系统地观察了人胎蓝斑酪氨酸羟化酶样免疫反应阳性神经元的发育。结果证明 :( 1)蓝斑酪氨酸羟化酶样神经元在胎龄 4个月时已经出现在蓝斑的腹侧部 ;( 2 )蓝斑酪氨酸羟化酶样神经元随胎龄增长逐渐增多 ,以 5个月时增加显著 ;( 3)酪氨酸羟化酶样神经元的密度在胚胎早期升高 ,晚期呈下降趋势 ;( 4)酪氨酸羟化酶样神经元主要分布在蓝斑的背侧部 ,少量散在于腹侧部 ;( 5)酪氨酸羟化酶样神经元开始出现时呈圆形或卵圆形 ,5～ 6个月时呈锥形和梭形 ,7～ 8个月时则以梭形、多角形为主。其胞体逐渐增大 ,胞浆逐渐增多 ,核浆之比由大变小 ,胞突从粗短变为细长平滑。本研究结果提示 ,人胎蓝斑移植以 4个月胎龄者作移植供体较为适宜 In order to explore the embryonic developmental characteristics of human blue-spot neurons and to select suitable gestational age for locus coeruleus-spinal cord transplantation to provide morphological basis, immunohistochemistry was used to systematically observe tyrosine hydroxylase-like immunity Development of reactive neurons. The results show that: (1) locus tyrosine hydroxylase-like neurons in the gestational age at 4 months has appeared in the ventral part of the locust; (2) locus tyrosine hydroxylase-like neurons with the fetal (3) The density of tyrosine hydroxylase-like neurons increased in the early embryos and decreased in the late embryos; (4) The tyrosine hydroxylase-like neurons (5) tyrosine hydroxylase-like neurons began to appear round or oval, 5-6 months when the cone-shaped and Fusiform, 7 to 8 months when the shuttle-shaped, polygonal-based. The cell body gradually increased, the cytoplasm gradually increased, the ratio of nuclear plasma from large to small, sudden change from coarse to short slender smooth. The results of this study suggest that it is more appropriate