论文部分内容阅读
目的观察氯沙坦对老年原发性高血压合并高尿酸血症患者的血压、血尿酸的影响,探讨其临床应用价值。方法随机选择69例老年原发性高血压合并高尿酸血症患者,经过1周的洗脱期后给予氯沙坦钾治疗,以25mg为起始剂量,按血压情况调整剂量直至达到目标值,最大用量100mg/d。治疗后8周观察用药前及用药后8周血压、血尿酸的变化。结果氯沙坦治疗后8周与治疗前比较,收缩压为(129.6±8.6vs174.7±17.2mmHg,P<0.05)、舒张压为(75.3±6.6vs95.5±10.2mmHg,P<0.05)明显下降,血尿酸水平显著降低(399.1±29.6vs446.1±30.8μmol/L,P<0.05)。结论氯沙坦降低老年原发性高血压患者血压同时能降低血尿酸,对肾脏有保护作用,适用于老年原发性高血压合并高尿酸血症的治疗。
Objective To observe the effects of losartan on blood pressure and serum uric acid in elderly patients with essential hypertension complicated with hyperuricemia and to explore its clinical value. Methods A total of 69 elderly patients with essential hypertension complicated with hyperuricemia were randomly selected and treated with losartan potassium after one week of elution. The dose of 25 mg was used as the starting dose. The dose was adjusted according to the blood pressure until the target value was achieved. The maximum amount of 100mg / d. Eight weeks after treatment, blood pressure and serum uric acid levels were observed before treatment and 8 weeks after treatment. Results Compared with before treatment, the systolic blood pressure was (129.6 ± 8.6vs174.7 ± 17.2mmHg, P <0.05) and the diastolic blood pressure was (75.3 ± 6.6vs95.5 ± 10.2mmHg, P <0.05) Decreased significantly, and serum uric acid level decreased significantly (399.1 ± 29.6 vs 446.1 ± 30.8μmol / L, P <0.05). Conclusion Losartan can reduce blood pressure and blood uric acid in senile patients with essential hypertension, and has protective effect on the kidney. It is suitable for the treatment of senile essential hypertension with hyperuricemia.