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为阐明支原体肺炎和腺病毒肺炎时一氧化氮(NO)和肿瘤环死因子(TNF)的变化,采用比色法、双抗体夹心ELISA法对32例支原体肺炎患儿、19例腺病毒肺炎患儿和20例健康儿进行血清NO、TNF测定。结果:支原体肺炎患儿血清NO、TNF为47.7±14.4μmol/L、37.1±9.8μg/L,和腺病毒肺炎患儿为68.2±13.9μmol/L、54.7±10.1μg/L,均较对照组(25.1±5.5μmol/L、8.2±2.9μg/L)明显升高,(P<0.01);而且NO、TNF呈显著正相关(r=0.816,P<0.01),两种病原之间比较,腺病毒肺炎患儿血清NO、TNF水平均高于支原体肺炎。提示:NO和TNF在腺病毒肺炎和支原体肺炎的发病机理中起一定作用。
To clarify the changes of nitric oxide (NO) and tumor necrosis factor (TNF) in mycoplasma pneumonia and adenovirus pneumonia, 32 cases of mycoplasma pneumonia, 19 cases of adenovirus pneumonia Children and 20 healthy children serum NO, TNF determination. Results: The serum NO and TNF in children with mycoplasma pneumonia were 47.7 ± 14.4μmol / L and 37.1 ± 9.8μg / L, respectively, and those in children with adenovirus pneumonia were 68.2 ± 13.9μmol / L and 54.7 ± 10.1μg / L, respectively (25.1 ± 5.5μmol / L, 8.2 ± 2.9μg / L) (P <0.01). There was a significant positive correlation between NO and TNF (r = 0.816, P <0.01) Adenovirus pneumonia in children with serum NO, TNF levels were higher than mycoplasma pneumonia. Tip: NO and TNF play a role in the pathogenesis of adenovirus pneumonia and mycoplasma pneumonia.