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目的探讨自拟经验方“活血健骨汤”对实验性激素致兔股骨头缺血性坏死的作用。方法选用１８只家兔随机分为激素，中药＋激素和对照三组实验观察，８周后处死全部动物，分析兔股骨标本的空骨陷窝数，血浆ＴＸＢ_２、６－Ｋｅｔｏ－ＰＧＦ_１α及ＴＸＡ_２／ＰＧＩ_２比值指标。结果中药＋激素组血浆 ＴＸＢ_２，ＴＸＡ_２／ＰＧＩ_２比值明显低于激素组（２１９．４２±６９．２２，４４９．３０±１１９．２２，０．９３±０．１３均Ｐ＜０．０１；６－Ｋｅｔｏ－ＰＧＦ_１α明显高于激素组（２４０．６４±８６．０３，１５６．５５±２８．１１，Ｐ＜０．０１），接近正常组（１６． ４１±６０． ６４，０． ６５±０． １５，２５０． ５１±４１．７０，均 Ｐ＞０． ０５）；中药十激素组的股骨头空骨陷窝数明显低于激素组而接近正常组（１３±２，２１±２，Ｐ＜０．０１；１３±２，１０±２，Ｐ＞０．０５）。结论活血健骨汤具有调节血浆ＴＸＢ_２和６－Ｋｅｔｏ－ＰＧＦ_１α水平，使ＴＸＡ_２／ＰＧＩ_２值趋于正常，同时能减少空骨陷窝数／率的作用，从而有效地预防和抑制实验性激素致兔股骨头缺血性坏死。
Objective To investigate the effect of “Huoxuejiangu Decoction” on the experimental hormonal induced avascular necrosis of the femoral head in rabbits. Methods Eighteen rabbits were randomly divided into three groups: hormone, Chinese medicine + hormone and control group. After 8 weeks, all animals were sacrificed. The number of empty bone lacunae in rabbit femur samples was analyzed. Plasma TXB_2, 6-Keto-PGF_1α and TXA_2/ PGI_2 ratio indicator. Results The plasma TXB_2 and TXA_2/PGI_2 ratios in the traditional Chinese medicine + hormone group were significantly lower than those in the hormone group (219.42±69.22, 449.30±119.22, 0.93±0.13 all P<0.01; 6- Keto-PGF_1α was significantly higher than the hormone group (240.64±86.03,156.55±28.11, P<0.01), and was close to the normal group (16.41±60.64, 0.55±0. 15,250.51±41.70, average P>0.05); The number of empty bone lacunae in the femoral head of Chinese medicine ten hormone group was significantly lower than that of hormone group and close to normal group (13±2,21±2, P< 0.01;13±2,10±2,P>0.05).Conclusion Huoxue Jiangu Decoction can regulate plasma TXB_2 and 6-Keto-PGF_1α level, make TXA_2/PGI_2 value normal, and reduce the empty bone at the same time. The role of lacunae/rate in order to effectively prevent and inhibit experimental hormone-induced femoral head defects in rabbits Necrosis.