患急性淋巴细胞白血病(ALL)的男孩比女孩预后差,这可能是睾丸成为残余细胞的“避难所”。有人倡用两侧睾丸的早期预防性放射,并在临床试验中评价。推荐这种放射疗法的作者认为:不孕症主要是全身化疗造成的,与睾丸内分泌功能无关,因为后者在照射中很少受损。虽然睾丸的生殖机能确实能为抗 ALL 化疗所损伤,且很少能及时恢复,但已报告一例成年男性 ALL患者在完成长疗程的连续治疗后不久正常生育。下面作者报告类似一例,所不同者在于此例是在青春发育期诊断为 ALL 的。当时患者在14岁2个月诊断为 ALL后,采用 UAKLLⅡ方案联合化疗,此方案未用环磷 Boys with acute lymphoblastic leukemia (ALL) have a poorer prognosis than girls, and this may be a “refuge” for the testicles to become residual cells. Some people advocate the prevention of early preventive radiation on both sides of the testes, and evaluated in clinical trials. The author of this radiation therapy recommendation argues that infertility is mainly caused by systemic chemotherapy and has nothing to do with testicular endocrine function because the latter are less damaged during irradiation. Although the reproductive function of the testis can indeed be harmed by anti-ALL chemotherapy and rarely resume promptly, one adult male with ALL has been reported to have normal childbirth shortly after completion of a long course of continuous treatment. The following authors report a similar case, except that this case is diagnosed as ALL at puberty. Patients were diagnosed with ALL at 14 years and 2 months after the combination of chemotherapy with UAKLL Ⅱ program, this program did not use cyclic phosphorus