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目的探讨a-硫辛酸治疗糖尿病周围神经病变的临床效果。方法选择糖尿病合并周围神经病变患者60例,分为治疗组(30例)和对照组(30例),对照组给予常规控制血糖及血栓通450 mg,每天1次,治疗组在对照组基础上加用硫辛酸600 mg,每天1次,治疗2周,并比较2组临床疗效。结果治疗组总有效率为93.3%,高于对照组的66.7%,差异具有统计学意义(P<0.05),且治疗组临床症状及体征改善明显。结论硫辛酸治疗糖尿病周围神经病变(DPN)效果显著,安全性高,值得临床推广应用。
Objective To investigate the clinical effect of a-lipoic acid on diabetic peripheral neuropathy. Methods Sixty patients with diabetes mellitus and peripheral neuropathy were divided into treatment group (30 cases) and control group (30 cases). The control group was given conventional blood sugar control and Xueshuantong 450 mg once daily. On the basis of the control group Add 600 mg of lipoic acid once daily for 2 weeks and compare the clinical efficacy of the two groups. Results The total effective rate in the treatment group was 93.3%, which was higher than that in the control group (66.7%), the difference was statistically significant (P <0.05). The clinical symptoms and signs of the treatment group were improved obviously. Conclusion Lipoic acid treatment of diabetic peripheral neuropathy (DPN) effect is significant, high safety, worthy of clinical application.